Migration and homing of immune cells are critical for immune surveillance. Trafficking is
mediated by combinations of adhesion and chemokine receptors that guide immune cells, in …

The androgen receptor (AR) signalling pathway has been intensively studied in the context
of prostate cancer, where androgen deprivation therapy is part of the standard of care for …

The safety of municipal sewage sludge has raised great concerns because of the
accumulation of large-scale endocrine disrupting chemicals in the sludge during wastewater …

T helper 2 (TH 2) cells orchestrate type 2 immunity during protective antihelminth immunity
and help restore tissue homoeostasis. Their misdirected activities against innocuous …

Hepatocellular carcinoma presents strong sexual dimorphism, being two to three times more
frequent in males than in females; however, the role of sex in response to immunotherapies …

There are differences in the prevalence of inflammatory diseases between the sexes (sexual
dimorphism), but the underlying mechanisms that regulate tissue immunity remain unclear …

The ability to heal from wounds is perhaps the most important biological function that
ensures our survival and perpetuation. Cutaneous wound healing typically consists of four …

The mechanisms driving sex differences in immunity are poorly understood and likely vary
by body site; thus Chi et al. investigated the mechanistic basis of sex differences in …

In their recent article in Science, Chi et al.[1] characterized a mechanism that regulates
tissue/organ-specific immunity in mice. Their findings revealed that the androgen type 2 …

Allergic disease is caused by the activation of allergen‐specific CD4+ type‐2 T follicular
helper cells (Tfh2) and T helper 2 (Th2) effector cells that secrete the cytokines IL‐4, IL‐5, IL …