The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
HIV reservoirs as obstacles and opportunities for an HIV cure
The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained
virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is …
virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is …
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
Chronic-phase HIV and simian immunodeficiency virus (SIV) replication is reduced by as
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …
TIGIT marks exhausted T cells, correlates with disease progression, and serves as a target for immune restoration in HIV and SIV infection
GM Chew, T Fujita, GM Webb, BJ Burwitz, HL Wu… - PLoS …, 2016 - journals.plos.org
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the
coordinated upregulation of a series of negative checkpoint receptors that eventually result …
coordinated upregulation of a series of negative checkpoint receptors that eventually result …
Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size
V Jain, W Hartogensis, P Bacchetti… - The Journal of …, 2013 - academic.oup.com
Abstract Background. CD4+/CD8+ T-cell activation levels often remain elevated in chronic
human immunodeficiency virus (HIV) infection despite initiation of antiretroviral therapy …
human immunodeficiency virus (HIV) infection despite initiation of antiretroviral therapy …
Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient
There is intense interest in developing curative interventions for HIV. How such a cure will
be quantified and defined is not known. We applied a series of measurements of HIV …
be quantified and defined is not known. We applied a series of measurements of HIV …
Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis
Objective: HIV-seropositive patients are at higher risk for atherosclerosis than HIV-
seronegative persons. This has been variably attributed to antiretroviral drug toxicity …
seronegative persons. This has been variably attributed to antiretroviral drug toxicity …
Cell-Based Measures of Viral Persistence Are Associated With Immune Activation and Programmed Cell Death Protein 1 (PD-1)–Expressing CD4+ T cells
Background. Studies aimed at defining the association between host immune responses
and human immunodeficiency virus (HIV) persistence during therapy are necessary to …
and human immunodeficiency virus (HIV) persistence during therapy are necessary to …
Towards an HIV-1 cure: measuring the latent reservoir
KM Bruner, NN Hosmane, RF Siliciano - Trends in microbiology, 2015 - cell.com
The latent reservoir (LR) of HIV-1 in resting memory CD4+ T cells serves as a major barrier
to curing HIV-1 infection. While many PCR-and culture-based assays have been used to …
to curing HIV-1 infection. While many PCR-and culture-based assays have been used to …
Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control
Many immune correlates of CD8+ T-cell-mediated control of HIV replication, including
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …