HIV-1 vaccine development has been stymied by an inability to induce broadly reactive neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
MS Saag, CA Benson, RT Gandhi, JF Hoy… - Jama, 2018 - jamanetwork.com
Importance Antiretroviral therapy (ART) is the cornerstone of prevention and management of HIV infection. Objective To evaluate new data and treatments and incorporate this …
How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …
KM Cirelli, DG Carnathan, B Nogal, JT Martin… - Cell, 2019 - cell.com
Conventional immunization strategies will likely be insufficient for the development of a broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
JP Casazza, EM Cale, S Narpala, GV Yamshchikov… - Nature medicine, 2022 - nature.com
Adeno-associated viral vector-mediated transfer of DNA coding for broadly neutralizing anti- HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination …
M Caskey, F Klein, MC Nussenzweig - Nature medicine, 2019 - nature.com
Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …
How precursor frequencies and antigen affinities impact interclonal B cell competition is a particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
Antibodies have been used for more than 100 years in the therapy of infectious diseases, but a new generation of highly potent and/or broadly cross-reactive human monoclonal …
A Esrafili, A Wagner, S Inamdar… - Advanced Healthcare …, 2021 - Wiley Online Library
Covalent organic frameworks (COFs) are porous organic polymeric materials that are composed of organic elements and linked together by the thermodynamically stable …