Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …

Mesenchymal stromal cells (MSCs) are heterogeneous and primitive cells discovered first in
the bone marrow (BM). They have putative roles in maintaining tissue homeostasis and are …

Abstract Background Mesenchymal stromal cells (MSCs) are attractive for cell-based
therapies ranging from regenerative medicine and tissue engineering to immunomodulation …

Aging at the cellular level is a complex process resulting from accumulation of various
damages leading to functional impairment and a reduced quality of life at the level of the …

Background Blood vessel formation is fundamental to development, while its dysregulation
can contribute to serious disease. Expectations are that hundreds of millions of individuals …

Summary 2018 was the year of the first marketing authorization of an allogeneic stem cell
therapy by the European Medicines Agency. The authorization concerns the use of …

Bone marrow (BM) contains a rare population of mesenchymal stromal cells (MSCs), which
have been characterized as nonhematopoietic skeletal progenitor cells with central …

Hematopoiesis is regulated by the bone marrow (BM) stroma. However, cellular identities
and functions of the different BM stromal elements in humans remain poorly defined. Based …

Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the
development of cell therapeutics in regenerative medicine. Featuring immunomodulatory …