Organoid systems leverage the self-organizing properties of stem cells to create diverse
multi-cellular tissue proxies. Most organoid models only represent single or partial …

Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …

Human pluripotent stem cells show considerable promise for applications in regenerative
medicine, including the development of cell replacement paradigms for the treatment of …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Parkinson disease (PD) is characterized by loss of the A9 nigral neurons that provide
dopaminergic innervation to the striatum. This discovery led to the successful instigation of …

After years of incremental progress, several recent studies have succeeded in deriving
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …

For the promise of human induced pluripotent stem cells (iPSCs) to be realized, it is
necessary to ask if and how efficiently they may be differentiated to functional cells of various …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

The transcriptional regulation of neuroectoderm (NE) specification is unknown. Here we
show that Pax6 is uniformly expressed in early NE cells of human fetuses and those …

Metabolites offer an important unexplored complementary approach to understanding the
pluripotency of stem cells. Using MS-based metabolomics, we show that embryonic stem …