The Gag proteins of HIV-1, like those of other retroviruses, are necessary and sufficient for
the assembly of virus-like particles. The roles played by HIV-1 Gag proteins during the life …

Recent work has illuminated three critical aspects of the cell biology of HIV-1 particle
genesis. First, we have come to understand which cellular membranes are selected as …

Exosomes are secreted, single membrane organelles of∼ 100 nm diameter. Their
biogenesis is typically thought to occur in a two-step process involving (1) outward vesicle …

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag
proteins are targeted to the plasma membrane of most hematopoietic cell types, where they …

HIV-1 particle production occurs in a series of steps promoted by the viral Gag protein.
Although it is well established that assembly and release take place at the plasma …

Exosomes are secreted organelles that have the same topology as the cell and bud outward
(outward is defined as away from the cytoplasm) from endosome membranes or endosome …

Retroviral assembly and budding is driven by the Gag polyprotein and requires the host‐
derived vacuolar protein sorting (vps) machinery. With the exception of human …

The myristoylated matrix protein (myr-MA) of HIV functions as a regulator of intracellular
localization, targeting the Gag precursor polyprotein to lipid rafts in the plasma membrane …

ABSTRACT Viral protein 40 (VP40) of Ebola virus appears equivalent to matrix proteins of
other viruses, yet little is known about its role in the viral life cycle. To elucidate the functions …

Exosomes are secreted cellular vesicles that can be internalized by dendritic cells (DCs),
contributing to antigen-specific naive CD4+ T-cell activation. Here, we demonstrate that …