Antimicrobial peptides: an update on classifications and databases
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …
indispensable component of host defenses. They consist of predominantly short cationic …
Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
[PDF][PDF] Accelerated antibacterial red-carbon dots with photodynamic therapy against multidrug-resistant Acinetobacter baumannii
W Liu, H Gu, B Ran, W Liu, W Sun, D Wang… - Science China …, 2022 - researchgate.net
The emergence of antibiotic resistance in bacteria is a major public-health issue. Synthesis
of efficient antibiotic-free material is very important for fighting bacterial infection-related …
of efficient antibiotic-free material is very important for fighting bacterial infection-related …
Paclitaxel and its derivative facilitate the transmission of plasmid-mediated antibiotic resistance genes through conjugative transfer
The rapid dissemination of antibiotic resistance by horizontal gene transfer (HGT) renders
the global resistance crisis more tense and urgent as few effective antimicrobials are …
the global resistance crisis more tense and urgent as few effective antimicrobials are …
Hydrogel Complex Containing the Antimicrobial Peptide HX‐12C Accelerates Healing of Infected Wounds
H Chen, Y Song, Y Peng, M Wang… - Macromolecular …, 2023 - Wiley Online Library
Bacterial infections of the wound surface can be painful for patients, and traditional
dressings do not effectively address this problem. In this study, an antimicrobial wound …
dressings do not effectively address this problem. In this study, an antimicrobial wound …
A molecular overview of the polymyxin-LPS interaction in the context of its mode of action and resistance development
I Padhy, SK Dwibedy, SS Mohapatra - Microbiological Research, 2024 - Elsevier
With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …
Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane …
Background MDR bacteria represent an urgent threat to human health globally. Polymyxins
are a last-line therapy against life-threatening Gram-negative 'superbugs', including …
are a last-line therapy against life-threatening Gram-negative 'superbugs', including …
Polymyxins induce lipid scrambling and disrupt the homeostasis of Gram-negative bacteria membrane
L Fu, X Li, S Zhang, Y Dong, W Fang, L Gao - Biophysical Journal, 2022 - cell.com
Polymyxins are increasingly used as the last-line therapeutic option for the treatment of
infections caused by multidrug-resistant Gram-negative bacteria. However, efforts to address …
infections caused by multidrug-resistant Gram-negative bacteria. However, efforts to address …
A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii
Multidrug-resistant Gram-negative bacteria represent a major medical challenge worldwide.
New antibiotics are desperately required with 'old'polymyxins often being the only available …
New antibiotics are desperately required with 'old'polymyxins often being the only available …
An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptides against Multidrug-Resistant Pseudomonas aeruginosa
Multidrug-resistant Gram-negative bacteria seriously threaten modern medicine due to the
lack of efficacious therapeutic options. Their outer membrane (OM) is an essential protective …
lack of efficacious therapeutic options. Their outer membrane (OM) is an essential protective …