The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to
allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to …

Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …

BACKGROUND: Commensal microbiota play a critical role in maintaining oral tolerance.
The effect of food allergy on the gut microbial ecology remains unknown. OBJECTIVE: We …

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are two major forms of innate
immune sensors, which provide immediate responses against pathogenic invasion or tissue …

The innate immune system is an ancient and diverse collection of defenses, including the
recognition of pathogens through the use of germline-encoded pathogen receptors. The …

Food allergy (FA), a growing public health burden in the United States, and familial
aggregation studies support strong roles for both genes and environment in FA risk …

BACKGROUND: NLR family, pyrin domain containing 3 (NLRP3), controls the activity of
inflammatory caspase-1 by forming inflammasomes, which leads to cleavage of the …

Adverse reactions to foods, aside from those considered toxic, are caused by a particular
individual intolerance towards commonly tolerated foods. Intolerance derived from an …

В последнее время накапливается все больше данных, свидетельствующих о том, что
полиморфизм единичных нуклеотидов (SNP) за счет формирования специфических …

BACKGROUND: Exposure to microbial agents might inhibit the development of atopy and
asthma. OBJECTIVE: We measured the association between microbial exposure assessed …