Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive
death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies …

Misfolded proteins are pathological findings in some chronic neurodegenerative disorders
including Alzheimer's, Parkinson's, and Huntington's diseases. Aging is a major risk factor …

Protein import into mitochondria is a highly regulated process, yet how cells clear
mitochondria undergoing dysfunctional protein import remains poorly characterized. Here …

Background Long non-coding RNA nuclear paraspeckle assembly transcript 1 (lncRNA
NEAT1) was found to be closely related to the pathological changes in brain and nervous …

Mutations in PTEN-induced kinase 1 (PINK1) result in a recessive familial form of
Parkinson's disease (PD). PINK1 loss is associated with mitochondrial Ca 2+ mishandling …

Abstract Bcl2-associated athanogene 2 (BAG2) shares a similar molecular structure and
function with other BAG family members. Functioning as a co-chaperone, it interacts with the …

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the
elderly population and is caused by the loss of dopaminergic neurons. PD has been …

The role of autoimmunity in Parkinson's disease (PD), as one of the most popular research
subjects, has been intensively investigated in recent years. Although the ultimate cause of …

Preservation of mitochondrial integrity is critical for maintaining cellular homeostasis.
Mitophagy is a mitochondria-specific type of autophagy which eliminates damaged …

Many studies reveal that BAG3 plays a critical role in the regulation of protein degradation
via macroautophagy. However, it remains unknown whether BAG3 affects the quality control …