Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Introduction: Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful
methodology to study protein dynamics, protein folding, protein-protein interactions, and …

Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) emerged as a tool for
biochemistry and structural biology around 25 years ago. It has since become a key …

The last∼ 25 years has seen mass spectrometry (MS) emerge as an integral method in the
structural biology toolkit. In particular, MS has enabled the structural characterization of …

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) probes dynamic motions of
proteins by monitoring the kinetics of backbone amide deuteration. Dynamic regions exhibit …

This article reviews the analytical aspects of measuring hydrogen exchange by mass
spectrometry (HX MS). We describe the nature of analytical selectivity in hydrogen …

Highlights•HDX-MS has been applied to develop both small and large molecule
therapeutics.•Recent improvements to experimental platforms and software have increased …

Celiac disease is triggered by partially digested gluten proteins. Enzyme therapies that
complete protein digestion in vivo could support a gluten-free diet, but the barrier to …

Many fundamental cellular processes are controlled via assembly of a network of proteins at
membrane surfaces. The proper recruitment of proteins to membranes can be controlled by …

Plants belonging to the genus Nepenthes are carnivorous, using specialized pitfall traps
called “pitchers” that attract, capture, and digest insects as a primary source of nutrients. We …