Vascular calcification—new insights into its mechanism

SJ Lee, IK Lee, JH Jeon - International journal of molecular sciences, 2020 - mdpi.com
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

[HTML][HTML] Osteopontin in bone metabolism and bone diseases

J Si, C Wang, D Zhang, B Wang, W Hou… - … medical journal of …, 2020 - ncbi.nlm.nih.gov
Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding
ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many …

Arterial calcification in chronic kidney disease: key roles for calcium and phosphate

CM Shanahan, MH Crouthamel, A Kapustin… - Circulation …, 2011 - Am Heart Assoc
Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney
disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is …

Biomedical applications of collagen

CH Lee, A Singla, Y Lee - International journal of pharmaceutics, 2001 - Elsevier
Collagen is regarded as one of the most useful biomaterials. The excellent biocompatibility
and safety due to its biological characteristics, such as biodegradability and weak …

Vascular calcification: pathobiology of a multifaceted disease

LL Demer, Y Tintut - Circulation, 2008 - Am Heart Assoc
with the matrix and with the periodicity of negative charges on collagen. Crystals initially
form octacalcium phosphate [Ca8H2 (PO4) 6· 5H2O], which reorganizes and seeds epitaxial …

Phosphate regulation of vascular smooth muscle cell calcification

S Jono, MD McKee, CE Murry, A Shioi… - Circulation …, 2000 - Am Heart Assoc
Vascular calcification is a common finding in atherosclerosis and a serious problem in
diabetic and uremic patients. Because of the correlation of hyperphosphatemia and vascular …

Osteopontin

J Sodek, B Ganss, MD McKee - Critical Reviews in Oral …, 2000 - journals.sagepub.com
Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of
the mineralized extracellular matrices of bones and teeth. OPN is characterized by the …

Arterial stiffness: a focus on vascular calcification and its link to bone mineralization

Y Chen, X Zhao, H Wu - Arteriosclerosis, thrombosis, and vascular …, 2020 - Am Heart Assoc
This review focuses on the association between vascular calcification and arterial stiffness,
highlighting the important genetic factors, systemic and local microenvironmental signals …

Vascular calcification: the killer of patients with chronic kidney disease

M Mizobuchi, D Towler… - Journal of the American …, 2009 - journals.lww.com
Cardiovascular complications are the leading cause of death in patients with chronic kidney
disease (CKD). Vascular calcification is a common complication in CKD, and investigators …

Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers

SA Steitz, MY Speer, G Curinga, HY Yang… - Circulation …, 2001 - Am Heart Assoc
Bovine aortic smooth muscle cell (BASMC) cultures undergo mineralization on addition of
the organic phosphate donor, β-glycerophosphate (βGP). Mineralization is characterized by …