Active and allosteric site binding MM-QM studies of Methylidene tetracyclo derivative in PCSK9 protein intended to make a safe antilipidemic agent

N Irfan, P Vaithyanathan, H Anandaram… - Journal of …, 2024 - Taylor & Francis
Interaction of low-density lipoprotein receptors with proprotein convertase subtilisin/kexin
type 9 (PCSK9) plays a vital part in causing atherosclerosis. It is the hidden precursor of …

PCSK9 inhibitors as safer therapeutics for atherosclerotic cardiovascular disease (ASCVD): Pharmacophore design and molecular dynamics analysis

IO Kehinde, O Akawa, AT Adewumi… - Journal of Cellular …, 2024 - Wiley Online Library
Cardiovascular disorders are still challenging and are among the deadly diseases. As a
major risk factor for atherosclerotic cardiovascular disease, dyslipidemia, and high low …

Molecular and Quantum Mechanical Studies of Interaction Between Tetrahydrocurcumin Derivative and PCSK9 Protein to Provide a Basis for an Oral Pill to Remove …

P Vaithyanathan - bioRxiv, 2023 - biorxiv.org
The interaction between Proprotein convertase subtilisin/kexin type 9 (PCSK9) and low-
density lipoprotein receptors responsible for causing atherosclerosis. According to …

Active and Allosteric Site Binding MOLECULAR MECHANICS-QUANTUM MECHANICS studies of STEVIOSIDE Derivative in PCSK9 Protein Intended to provide a …

N Irfan, P Vaithyanathan, H Anandaram, SM Zaidh… - bioRxiv, 2023 - biorxiv.org
Interaction of low-density lipoprotein receptors with proprotein convertase subtilisin/kexin
type 9 (PCSK9) plays a vital role in causing atherosclerosis. It is the hidden precursor of …

Analysis of an Insilico Interaction by a Curcumin Derivative Specifically Only With the Akt1 Molecule but not Akt2

P Vaithyanathan - 2023 - researchsquare.com
Akt1 is an important macromolecule expressed excessively in many cancers. Inhibition of
Akt1 by natural compounds is always advantageous for there are fewer side effects. It is well …