Gut microbiota-derived metabolites as central regulators in metabolic disorders

A Agus, K Clément, H Sokol - Gut, 2021 - gut.bmj.com
Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

SCFA: mechanisms and functional importance in the gut

C Martin-Gallausiaux, L Marinelli… - Proceedings of the …, 2021 - cambridge.org
In recent years, the importance of the gut microbiota in human health has been revealed and
many publications have highlighted its role as a key component of human physiology …

[HTML][HTML] Free fatty acid receptors in health and disease

I Kimura, A Ichimura, R Ohue-Kitano… - Physiological …, 2019 - journals.physiology.org
Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …

Emerging pathogenic links between microbiota and the gut–lung axis

KF Budden, SL Gellatly, DLA Wood… - Nature Reviews …, 2017 - nature.com
The microbiota is vital for the development of the immune system and homeostasis.
Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and …

Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases

T Ikeda, A Nishida, M Yamano, I Kimura - Pharmacology & therapeutics, 2022 - Elsevier
Dysbiosis is associated with various diseases. The composition and diversity of gut
microbiota affect host physiology through the production of bioactive metabolites. Short …

Participation of short-chain fatty acids and their receptors in gut inflammation and colon cancer

MD Carretta, J Quiroga, R López, MA Hidalgo… - Frontiers in …, 2021 - frontiersin.org
Short-chain fatty acids (SCFAs) are the main metabolites produced by the bacterial
fermentation of dietary fiber, and they play a critical role in the maintenance of intestinal …

Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model

TS Rasmussen, CMJ Mentzel, W Kot, JL Castro-Mejía… - Gut, 2020 - gut.bmj.com
Objective Development of obesity and type 2 diabetes (T2D) are associated with gut
microbiota (GM) changes. The gut viral community is predominated by bacteriophages …

[HTML][HTML] Mechanisms of short-chain fatty acids derived from gut microbiota in Alzheimer's disease

X Qian, R Xie, X Liu, H Tang - Aging and disease, 2022 - ncbi.nlm.nih.gov
Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota
through fermentation of dietary fiber. SCFAs participate a number of physiological and …

The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

[HTML][HTML] Role of short chain fatty acid receptors in intestinal physiology and pathophysiology

M Priyadarshini, KU Kotlo, PK Dudeja… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
Nutrient sensing is a mechanism for organisms to sense their environment. In larger
animals, including humans, the intestinal tract is a major site of nutrient sensing for the body …