Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …

Dissection of complex biological systems requires target-specific control of the function or
abundance of proteins. Genetic perturbations are limited by off-target effects …

Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering
maladaptive cell state transitions. Fibroblast activation is a common stress response in …

Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …

The development of effective pharmacological inhibitors of multidomain scaffold proteins,
notably transcription factors, is a particularly challenging problem. In part, this is because …

Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-
limiting event in human gene control. A small number of regulatory factors influence …

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant
acetylation levels have been linked to the development of several diseases. Acetyl-lysine …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …