Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent
cytokines in mediating antitumor activity in a variety of preclinical models. Through …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Abstract Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that induces the
production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and …

The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

Abstract Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated
antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play …

Abstract Interleukin 35 (IL-35) belongs to the IL-12 family of heterodimeric cytokines but has
a distinct functional profile. IL-35 suppresses T cell proliferation and converts naive T cells …

Adoptive immunotherapy with T cells genetically modified to express chimeric antigen
receptors (CARs) is a promising approach to improve outcomes for cancer patients. While …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that,
expressed by different cell types, has regulatory effects on T cells resulting from tryptophan …