Lipoxygenases (LOX) play critical roles in mammalian biology in the generation of potent
lipid mediators of the inflammatory response; consequently, they are targets for the …

The enzyme encoded by the ALOX15B gene has been linked to the development of
atherosclerotic plaques in humans and in a mouse model of hypercholesterolemia. In vitro …

The enzyme N5‐carboxylaminoinidazole ribonucleotide (N5‐CAIR) mutase is found in
microbial de novo purine biosynthesis but is absent in humans making it an attractive …

The continued rise of antibiotic-resistant infections coupled with the limited pipeline of new
antimicrobials highlights the pressing need for the development of new antibacterial agents …

De novo purine biosynthesis is one of two pathways for the synthesis of purine nucleotides
that are critical for numerous biological processes, most notably nucleic acid replication …

Structures of (N5)-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus
anthracis with various combinations of ATP, ADP, Mg2+, bicarbonate and aminoimidazole …

Isatin has been identified in a diverse range of organisms, including microorganism, plants,
invertebrates and vertebrates. In the species that have been investigated, the biosynthesis …

The de novo purine biosynthesis pathway plays a critical role in providing new purines to the
cell. Previous studies have shown differences between the human and bacterial pathways …

Design, Synthesis and Biological Evaluation of Pyrido [2, 3-D] Pyrimidines as Inhibitors of N
5-Cair Synthetase Abstract The spread of drug-resistant bacterial infections has increased …

The de novo purine biosynthesis is an essential life sustaining process in many organisms,
including bacterial pathogens. My work investigates the structural and functional properties …