Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a
painful and long-lasting disorder with profound somatosensory deficits. There are no …

The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine
by the Dus family of NADPH-dependent reductases and is typically found within the eponym …

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for redox enzymes, but
also moonlights as a regulator for ion channels, the same as its metabolites. Ca2+ …

Transient receptor potential melastatin 2 (TRPM2) is a ligand-gated Ca2+-permeable
nonselective cation channel. Whereas physiological stimuli, such as chemotactic agents …

We here described a three-step multi-enzymatic reaction for the one-pot synthesis of
vidarabine 5′-monophosphate (araA-MP), an antiviral drug, using arabinosyluracil (araU) …

7, 030, 118 B2 7, 091, 232 B2 7, 498, 409 B2 7, 524, 852 B2 7, 531, 547 B2 7, 754, 728 B2
7, 923, 554 B2 8, 012, 964 B2 8, 022, 077 B2 8, 455, 458 B2 8, 486, 952 B2 8, 637, 525 B2 …

US9284304B2 - Substituted pyrimidines as toll-like receptor modulators - Google Patents
US9284304B2 - Substituted pyrimidines as toll-like receptor modulators - Google Patents …

Cyclic N 1-pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of
cyclic ADP-ribose (cADPR) in which the N 1-pentyl chain and the monophosphate group …

A method to ribosylate adenosine on the 2′ hydroxyl function in an α-selective fashion and
in good yield is presented. Protective groups chosen for the acceptor and donor used in this …

Two nicotinamide adenine dinucleotide (NAD+) analogues modified at the 6 position of the
purine ring were synthesized, and their substrate properties toward Aplysia californica ADP …