L-Nucleosides are the enantiomers of the natural nucleosides which have an inverted
configuration at all chiral centers (Fig. 1). By analogy with the natural D-nucleosides, a …

Natural d-nucleosides are no longer the sole basis for designing effective antiviral
analogues. Many antivirals with an opposite (l) configuration were reported, with lamivudine …

UMP‐CMP kinase catalyses an important step in the phosphorylation of UTP, CTP and
dCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside …

ABSTRACT A series of unnatural l-nucleosides such as 3TC, FTC and l-FMAU have been
found to be potent antiviral agents. The mode of action of l-nucleosides has been found to …

Deoxynucleoside kinases catalyze the 5 '-phosphorylation of 2 '-deoxyribonucleosides with
nucleoside triphosphates as phosphate donors. One of the cellular kinases, deoxycytidine …

Jay A. Glasel: Drugs, the human genome, and individual-based medicine.-Vera M. Kolb:
Herbal medicine of Wisconsin Indians.-Paul L. Skatrud: The impact of multiple drug …

This review is primarily intended for synthetic bio-organic chemists and enzymologists who
are interested in new strategies in the design of virus inhibitors. It is an attempt to assess the …

Our discovery that Herpes virus thymidine kinase (TK) and cellular deoxycytidine kinase lack
enantioselectivity, being able to phosphorylate both d-and l-enantiomers of the substrate …

A set of deazaguanine derivatives 1− 3 targeting human purine nucleoside phosphorylase
(hPNP) have been designed and synthesized. The new compounds are characterized by …

The reverse transcriptase inhibitors still represent the majority of the clinically used anti-HIV
drugs and constitute the main backbone of currently employed combinatorial regimens. A …