There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …

For years, the consumption of a diet rich in fruits and vegetables has been considered
healthy, increasing longevity, and decreasing morbidities. With the assistance of basic …

Estrogen deficiency has been considered the seminal mechanism of osteoporosis in both
women and men, but epidemiological evidence in humans and recent mechanistic studies …

The reactive oxygen species that are generated by mitochondrial respiration, including
hydrogen peroxide (H2O2), are potent inducers of oxidative damage and mediators of …

Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …

Sirtuins are an evolutionarily conserved family of NAD+-dependent deacylases that display
diversity in subcellular localization and function. SIRT2, the predominantly cytosolic sirtuin …

In the CNS, the hypothalamic arcuate nucleus (ARN) energy-balance circuit plays a key role
in regulating body weight. Recent studies have shown that neurogenesis occurs in the adult …

Aging is well-known an inevitable process that is influenced by genetic, lifestyle and
environmental factors. However, the exact mechanisms underlying the aging process are …