Mapping epigenetic modifications by sequencing technologies
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
Emerging role of different DNA methyltransferases in the pathogenesis of cancer
P Liu, F Yang, L Zhang, Y Hu, B Chen… - Frontiers in …, 2022 - frontiersin.org
DNA methylation is one of the most essential epigenetic mechanisms to regulate gene
expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the …
expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the …
TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
The myeloid transcription factor CEBPA is recurrently biallelically mutated (ie, double
mutated; CEBPA DM) in acute myeloid leukemia (AML) with a combination of hypermorphic …
mutated; CEBPA DM) in acute myeloid leukemia (AML) with a combination of hypermorphic …
Dysregulated immune and metabolic pathways are associated with poor survival in adult acute myeloid leukemia with CEBPA bZIP in-frame mutations
Acute myeloid leukemia (AML) with CEBPA bZIP in-frame mutations (CEBPA bZIP-inf) is
classified within the favorable-risk group by the 2022 European LeukemiaNet (ELN-2022) …
classified within the favorable-risk group by the 2022 European LeukemiaNet (ELN-2022) …
RUNX1/CEBPA mutation in acute myeloid leukemia promotes hypermethylation and indicates for demethylation therapy
EI Romanova, AV Zubritskiy, AV Lioznova… - International Journal of …, 2022 - mdpi.com
Acute myeloid leukemia (AML) is a rapidly progressing heterogeneous disease with a high
mortality rate, which is characterized by hyperproliferation of atypical immature myeloid …
mortality rate, which is characterized by hyperproliferation of atypical immature myeloid …
DNMT3A Cooperates with YAP/TAZ to Drive Gallbladder Cancer Metastasis
S Xu, Z Yuan, C Jiang, W Chen, Q Li… - Advanced …, 2024 - Wiley Online Library
Gallbladder cancer (GBC) is an extremely lethal malignancy with aggressive behaviors,
including liver or distant metastasis; however, the underlying mechanisms driving the …
including liver or distant metastasis; however, the underlying mechanisms driving the …
Targeting DNA methylation in leukemia, myelodysplastic syndrome, and lymphoma: a potential diagnostic, prognostic, and therapeutic tool
L Kalinkova, A Sevcikova, V Stevurkova… - International Journal of …, 2022 - mdpi.com
DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic
malignancies. The methylation process is controlled by specific DNA methyl transferases …
malignancies. The methylation process is controlled by specific DNA methyl transferases …
[HTML][HTML] Germline structural variation globally impacts the cancer transcriptome including disease-relevant genes
F Chen, Y Zhang, FJ Sedlazeck, CJ Creighton - Cell Reports Medicine, 2024 - cell.com
Germline variation and somatic alterations contribute to the molecular profile of cancers. We
combine RNA with whole genome sequencing across 1,218 cancer patients to determine …
combine RNA with whole genome sequencing across 1,218 cancer patients to determine …
[HTML][HTML] Challenges and advances in the management of inflammation in atherosclerosis
Y Xing, X Lin - Journal of Advanced Research, 2024 - Elsevier
Introduction Atherosclerosis, traditionally considered a lipid-related disease, is now
understood as a chronic inflammatory condition with significant global health implications …
understood as a chronic inflammatory condition with significant global health implications …
The roles of ubiquitination in AML
Z Wei, L Su, S Gao - Annals of Hematology, 2023 - Springer
Acute myeloid leukemia (AML) is a heterogeneously malignant disorder resulting in poor
prognosis. Ubiquitination, a major post-translational modification (PTM), plays an essential …
prognosis. Ubiquitination, a major post-translational modification (PTM), plays an essential …