Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation–Processing aspects and challenges

A Bhakay, M Rahman, RN Dave, E Bilgili - Pharmaceutics, 2018 - mdpi.com
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …

Progress in the development of stabilization strategies for nanocrystal preparations

J Li, Z Wang, H Zhang, J Gao, A Zheng - Drug Delivery, 2021 - Taylor & Francis
In recent years, nanocrystal technology has been extensively investigated. Due to the
submicron particle size and unique physicochemical properties of nanocrystals, they …

Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs

M Davis, G Walker - Journal of Controlled Release, 2018 - Elsevier
Poorly water-soluble drugs are a significant and ongoing issue for the pharmaceutical
industry. An overview of recent developments for the preparation of spray-dried delivery …

Preparation of luliconazole nanocrystals loaded hydrogel for improvement of dissolution and antifungal activity

M Kumar, N Shanthi, AK Mahato, S Soni… - Heliyon, 2019 - cell.com
Superficial fungal infection in immunocompromised patients can lead to many disorders and
complications. Currently, new topical treatment options are critically needed to treat these …

[HTML][HTML] Maternal and severe anaemia in delivering women is associated with risk of preterm and low birth weight: A cross sectional study from Jharkhand, India

S Kumari, N Garg, A Kumar, PKI Guru, S Ansari… - One Health, 2019 - Elsevier
Background and objectives Haemoglobin content is the well accepted indicator for anaemia
assessment. The high prevalence of anaemia, maternal health care issues and adverse …

Design space and QbD approach for production of drug nanocrystals by wet media milling techniques

L Peltonen - Pharmaceutics, 2018 - mdpi.com
Drug nanocrystals are nanosized solid drug particles, the most important application of
which is the improvement of solubility properties of poorly soluble drug materials. Drug …

Mechanistic modeling of wet stirred media milling for production of drug nanosuspensions

E Bilgili, G Guner - AAPS PharmSciTech, 2021 - Springer
Drug nanocrystals have been used for a wide range of drug delivery platforms in the
pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble …

Spray-dried PulmoSphere™ formulations for inhalation comprising crystalline drug particles

JG Weers, DP Miller, TE Tarara - AAPS PharmSciTech, 2019 - Springer
Over the past 20 years, solution-based spray dried powders have transformed inhaled
product development, enabling aerosol delivery of a wider variety of molecules as dry …

Production of cocrystals in an excipient matrix by spray drying

D Walsh, DR Serrano, ZA Worku, BA Norris… - International Journal of …, 2018 - Elsevier
Spray drying is a well-established scale-up technique for the production of cocrystals.
However, to the best of our knowledge, the effect of introducing a third component into the …

Dual centrifugation–a new technique for nanomilling of poorly soluble drugs and formulation screening by an DoE-approach

M Hagedorn, A Bögershausen, M Rischer… - International journal of …, 2017 - Elsevier
The development of nanosuspensions of poorly soluble APIs takes a lot of time and high
amount of active material is needed. In this publication the use of dual centrifugation (DC) for …