Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …
socioeconomic implications for patients and their care-givers. Recent advances in medical …
Claudin-5: gatekeeper of neurological function
C Greene, N Hanley, M Campbell - Fluids and Barriers of the CNS, 2019 - Springer
Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …
Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood–brain barrier permeability via …
Background Blood–brain barrier (BBB) disruption is a major adverse event after ischemic
stroke (IS). Caveolin-1 (Cav-1), a scaffolding protein, played multiple roles in BBB …
stroke (IS). Caveolin-1 (Cav-1), a scaffolding protein, played multiple roles in BBB …
Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5)
Z Yang, P Lin, B Chen, X Zhang, W Xiao, S Wu… - Autophagy, 2021 - Taylor & Francis
Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the
central nervous system (CNS) under stroke, and is frequently associated with abnormal …
central nervous system (CNS) under stroke, and is frequently associated with abnormal …
Autophagy-and MMP-2/9-mediated reduction and redistribution of ZO-1 contribute to hyperglycemia-increased blood–brain barrier permeability during early …
Post-stroke hyperglycemia during early reperfusion increases blood–brain barrier (BBB)
permeability and subsequently aggravates brain injury and clinical prognosis. The …
permeability and subsequently aggravates brain injury and clinical prognosis. The …
Autophagy at the interface of endothelial cell homeostasis and vascular disease
E Mameli, A Martello, A Caporali - The FEBS journal, 2022 - Wiley Online Library
Autophagy is an essential intracellular process for cellular quality control. It enables cell
homeostasis through the selective degradation of harmful protein aggregates and damaged …
homeostasis through the selective degradation of harmful protein aggregates and damaged …
Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd. 3 brain endothelial cells and rat ischemic stroke …
KA Kim, D Kim, JH Kim, YJ Shin, ES Kim… - Fluids and Barriers of …, 2020 - Springer
Background The blood–brain barrier (BBB) maintains homeostasis of the brain environment
by tightly regulating the entry of substances from systemic circulation. A breach in the BBB …
by tightly regulating the entry of substances from systemic circulation. A breach in the BBB …
Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1/MMP2/9 pathway after …
Background The leakage of blood-brain barrier (BBB) is main pathophysiological change in
acute stage of ischemic stroke, which not only deteriorates neurological function, but also …
acute stage of ischemic stroke, which not only deteriorates neurological function, but also …
Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex‐dependent manner
Iron imbalance in the brain negatively affects brain function. With aging, iron levels increase
in the brain and contribute to brain damage and neurological disorders. Changes in the …
in the brain and contribute to brain damage and neurological disorders. Changes in the …
Mechanisms of deoxynivalenol-induced endocytosis and degradation of tight junction proteins in jejunal IPEC-J2 cells involve selective activation of the MAPK …
Mycotoxin contamination in foods is a major risk factor for human and animal health due to
its prevalence in cereals and their by-products. Deoxynivalenol (DON), mainly produced by …
its prevalence in cereals and their by-products. Deoxynivalenol (DON), mainly produced by …