Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 …

Neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, and
Parkinson's disease, are a class of diseases that lead to dysfunction of cognition and …

Huntington's disease is a fatal neurodegenerative disorder resulting from a CAG repeat
expansion in the first exon of the gene encoding the Huntingtin protein (Htt) …

Many neurodegenerative diseases are characterized by impairment of protein quality control
mechanisms in neuronal cells. Ineffective clearance of misfolded proteins by the …

Phosphorylation of the N‐terminal domain of the huntingtin (HTT) protein has emerged as
an important regulator of its localization, structure, aggregation, clearance and toxicity …

Huntington's disease (HD) is an extraordinary disorder that usually strikes when individuals
are in the prime of their lives, as was the case for the influential 20th century musician …

Protein quantification techniques such as immunoassays have been improved considerably,
but they have several limitations, including time‐consuming procedures, low sensitivity, and …

OBJECTIVE: Huntington's disease is a dominant autosomal inherited neurodegenerative
disease that results in progressive impairment, characterized by dementia, chorea, and …

Especially in higher eukaryotes, the N termini of proteins are subject to enzymatic
modifications, with the acetylation of the alpha‐amino group of nascent polypeptides being a …

Cells are fundamental units of life. To ensure the maintenance of homeostasis, integrity of
structural and functional counterparts is needed to be essentially balanced. The …