In the adult nervous system, the major source of nucleotide synthesis is the salvage
pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine …

Astroglial cells were long considered to serve merely as the structural and metabolic
supporting cast and scenery against which the shining neurones perform their illustrious …

Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central
nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the …

Over the last decade, a large body of information regarding the amino acid sequences and
tertiary structures of many proteins has accumulated. Subtle similarities in sequence …

In a situation so far unique among neurotransmitter receptors, glutamate receptors share
amino acid sequence similarities with the bacterial periplasmic binding proteins (PBPs). On …

The chick cerebellar kainate (KA) binding protein (KBP), a member of the family of ionotropic
glutamate receptors, harbours a glycine‐rich (GxGxxG) motif known to be involved in the …

We investigated the potential of ATP to inhibit heterologously expressed NMDA receptor
subunit combinations, NMDA-induced currents in cultured hippocampal cells, and NMDA …

When injected into the rat striatum, quinolinic acid causes dose-dependent widespread cell
death. All cell types, including the NADPH-diaphorase-positive neurons appear to be …

Recent advances have demonstrated that the family of 13Hlkainate-binding proteins and
kainate receptors comprise a number of related polypeptides. In all the cases so far …

In G protein-coupled receptors, neurotransmitter-induced binding of GTP to G proteins
triggers the activation of effector systems while simultaneously decreasing the affinity of the …