Estrogens play an important role in regulating the growth and differentiation of normal,
premalignant and malignant cell types, especially breast epithelial cells, through interaction …

Highlights•Endocrine treatment resistance in estrogen receptor positive breast
cancer.•Technological advancements for the discovery of biomarkers of endocrine …

In estrogen target cells, estrogen receptor-α (ERα) protein levels are strictly regulated.
Although receptor turnover is a continuous process, dynamic fluctuations in receptor levels …

Genistein and apigenin are phytoestrogens present in commercial preparations used for the
treatment of postmenopausal symptoms. In this study, we assessed the influence of these …

Cellular levels of estrogen receptor-α (ERα) protein are regulated primarily by the ubiquitin-
proteasome pathway. Dynamic interactions between ERα and the protein degradation …

We designed and synthesized estrogen receptor (ER) degradation inducers 5, 6, and 7,
which crosslink the ER and the cellular inhibitor of apoptosis protein 1 (cIAP1). Compounds …

Awareness of the regulation of cell signaling by post-translational ubiquitination has
emerged over the past 2 decades. Like phosphorylation, post-translational modification of …

Tamoxifen remains a cornerstone of adjuvant therapy for patients with early stage breast
cancer and oestrogen-receptor-positive tumours. Accurate markers of tamoxifen resistance …

Estrogen receptors (α and ß) are members of the steroid/thyroid nuclear receptors
superfamily of ligand-dependent transcription factors. Impact of the? isoform of estrogen …

Targeting selective estrogen subtype receptors through typical medicinal chemistry
approaches is based on occupancy-driven pharmacology. In occupancy-driven …