D-ribose metabolic disorder and diabetes mellitus
Y Tai, Z Zhang, Z Liu, X Li, Z Yang, Z Wang, L An… - Molecular biology …, 2024 - Springer
D-ribose, an ubiquitous pentose compound found in all living cells, serves as a vital
constituent of numerous essential biomolecules, including RNA, nucleotides, and riboflavin …
constituent of numerous essential biomolecules, including RNA, nucleotides, and riboflavin …
Cheminformatics-based discovery of new organoselenium compounds with potential for the treatment of cutaneous and visceral leishmaniasis
Leishmaniasis affects more than 12 million humans globally and a further 1 billion people
are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis coupled …
are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis coupled …
Theoretical activity prediction, structure-based design, molecular docking and pharmacokinetic studies of some maleimides against Leishmania donovani for the …
Background Leishmaniasis is a neglected tropical disease caused by a group of protozoan
of the genus Leishmani a and transmitted to humans majorly through the bite of the female …
of the genus Leishmani a and transmitted to humans majorly through the bite of the female …
Computational evaluation of the inhibitory potential of some urea, thiourea, and selenourea derivatives of diselenides against leishmaniasis: 2D-QSAR …
Leishmaniasis affects more than twelve million people globally and a further one billion
people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …
people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …
Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani
The enzyme pyridoxal kinase (PdxK) catalyzes the conversion of pyridoxal to pyridoxal-5′-
phosphate (PLP) using ATP as the co-factor. The product pyridoxal-5′-phosphate plays a …
phosphate (PLP) using ATP as the co-factor. The product pyridoxal-5′-phosphate plays a …
[HTML][HTML] Conformational flexibility of human ribokinase captured in seven crystal structures
Abstract d-ribose is a critical sugar substrate involved in the biosynthesis of nucleotides,
amino acids, and cofactors, with its phosphorylation to ribose-5-phosphate by ribokinase …
amino acids, and cofactors, with its phosphorylation to ribose-5-phosphate by ribokinase …
Identification of potential antileishmanial agents via structure-based molecular simulations
N Razzaghi-Asl, N Hashemi - Journal of Molecular Graphics and Modelling, 2022 - Elsevier
Leishmaniasis is a parasitic disease with frequent annual incidence. An important issue in
chemotherapy is the emergence of resistance, toxicity and lack of cost-effectiveness within …
chemotherapy is the emergence of resistance, toxicity and lack of cost-effectiveness within …
Pyridoxal Kinase of Disease-causing Human Parasites: Structural and Functional Insights to Understand its Role in Drug Discovery
M Saini, S Are, IA Qureshi - Current Protein and Peptide …, 2022 - ingentaconnect.com
Human parasites cause several diseased conditions with high morbidity and mortality in a
large section of the population residing in various geographical areas. Nearly three billion …
large section of the population residing in various geographical areas. Nearly three billion …
Cheminformatic evaluation of the multi-protein binding potential of some diselenide derivatives: A plausible drug discovery approach for leishmaniasis
Over twelve million individuals worldwide suffer from leishmaniasis, and an additional billion
people are at risk in places where the disease is prevalent. This work was motivated by the …
people are at risk in places where the disease is prevalent. This work was motivated by the …
Multi-protein targeting potential of some urea, thiourea, and selenourea derivatives of diselenides in leishmaniasis: molecular docking screening, oral bioavailability …
Leishmaniasis affects more than twelve million people globally and a further one billion
people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …
people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …