Advances in oral drug delivery for regional targeting in the gastrointestinal tract-influence of physiological, pathophysiological and pharmaceutical factors

S Hua - Frontiers in pharmacology, 2020 - frontiersin.org
The oral route is by far the most common route of drug administration in the gastrointestinal
tract and can be used for both systemic drug delivery and for treating local gastrointestinal …

Mucoadhesive carriers for oral drug delivery

R Kumar, T Islam, M Nurunnabi - Journal of Controlled Release, 2022 - Elsevier
Among the various dosage forms, oral medicine has extensive benefits including ease of
administration and patients' compliance, over injectable, suppositories, ocular and nasal …

Application of chitosan and its derivative polymers in clinical medicine and agriculture

M Zhang, F Zhang, C Li, H An, T Wan, P Zhang - Polymers, 2022 - mdpi.com
Chitosan is a biodegradable natural polymer derived from the exoskeleton of crustaceans.
Because of its biocompatibility and non-biotoxicity, chitosan is widely used in the fields of …

Advances in oral absorption of polysaccharides: Mechanism, affecting factors, and improvement strategies

Z Zheng, X Pan, L Luo, Q Zhang, X Huang, Y Liu… - Carbohydrate …, 2022 - Elsevier
Polysaccharides have been widely used as biomaterials and drugs after oral administration
due to their suitable physicochemical properties, good bioactivities and low toxicities …

A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

RM Rasul, MT Muniandy, Z Zakaria, K Shah… - Carbohydrate …, 2020 - Elsevier
Chitosan, as a biodegradable and biocompatible polymer, is characterized by anti-microbial
and anti-cancer properties. It lately has received a widespread interest for use as the …

The role of tight junctions in skin barrier function and dermal absorption

K Bäsler, S Bergmann, M Heisig, A Naegel… - Journal of Controlled …, 2016 - Elsevier
The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

Intranasal vaccine: Factors to consider in research and development

H Xu, L Cai, S Hufnagel, Z Cui - International journal of pharmaceutics, 2021 - Elsevier
Most existing vaccines for human use are administered by needle-based injection.
Administering vaccines needle-free intranasally has numerous advantages over by needle …

Solid lipid nanoparticles for enhanced oral absorption: A review

E Salah, MM Abouelfetouh, Y Pan, D Chen… - colloids and surfaces B …, 2020 - Elsevier
Recent trends in nanoparticles-based oral therapy have led to a proliferation of studies to
enhance solubility, permeability and chemical stability of many drugs. One of the significant …

The challenges of oral drug delivery via nanocarriers

J Reinholz, K Landfester, V Mailänder - Drug delivery, 2018 - Taylor & Francis
The oral application of pharmaceuticals is unarguably the most convenient method of
application. Especially for protein-or peptide-based drugs, however, the effectiveness is …

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) as food-grade nanovehicles for hydrophobic nutraceuticals or bioactives

CH Tang, HL Chen, JR Dong - Applied Sciences, 2023 - mdpi.com
Although solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have
been successfully used as drug delivery systems for about 30 years, the usage of these …