[HTML][HTML] Recent advances in screening of enzymes inhibitors based on capillary electrophoresis

M Cheng, Z Chen - Journal of pharmaceutical analysis, 2018 - Elsevier
Capillary electrophoresis with many advantages plays an important role in pharmaceutical
analysis and drug screening. This review gives an overview on the recent advances in the …

Advances in enzyme substrate analysis with capillary electrophoresis

S Gattu, CL Crihfield, G Lu, L Bwanali, LM Veltri… - Methods, 2018 - Elsevier
Capillary electrophoresis provides a rapid, cost-effective platform for enzyme and substrate
characterization. The high resolution achievable by capillary electrophoresis enables the …

Multipurpose HTS coagulation analysis: Assay development and assessment of coagulopathic snake venoms

KBM Still, RSS Nandlal, J Slagboom, GW Somsen… - Toxins, 2017 - mdpi.com
Coagulation assays currently employed are often low throughput, require specialized
equipment and/or require large blood/plasma samples. This study describes the …

[HTML][HTML] Advances in tumor-endothelial cells co-culture and interaction on microfluidics

W Li, M Khan, S Mao, S Feng, JM Lin - Journal of pharmaceutical analysis, 2018 - Elsevier
The metastasis in which the cancer cells degrade the extracellular matrix (ECM) and invade
to the surrounding and far tissues of the body is the leading cause of mortality in cancer …

Advances in capillary electrophoresis-based enzyme assays

GKE Scriba, F Belal - Chromatographia, 2015 - Springer
Capillary electrophoresis (CE) has become a flexible and accurate, high-efficiency analytical
separation technique in many areas requiring only minute amounts of sample and …

An online dual-enzyme co-immobilized microreactor based on capillary electrophoresis for enzyme kinetics assays and screening of dual-target inhibitors against …

ZY Wu, H Zhang, YY Yang, FQ Yang - Journal of Chromatography A, 2020 - Elsevier
In this study, an online capillary electrophoresis (CE) based dual-enzyme (thrombin and
factor Xa) co-immobilized microreactor (THR-FXa IMER) was constructed for studying …

Capillary electrophoresis in the context of drug discovery

E Farcaş, L Pochet, J Crommen, AC Servais… - … of pharmaceutical and …, 2017 - Elsevier
Capillary Electrophoresis is a very efficient and resolutive separation technique used for
many years in the analytical field. Despite all its assets, CE remains poorly used in drug …

On-line immobilized trypsin microreactor for evaluating inhibitory activity of phenolic acids by capillary electrophoresis and molecular docking

H Zhang, ZY Wu, YZ Wang, DD Zhou, FQ Yang, DQ Li - Food chemistry, 2020 - Elsevier
Phenolic acids, which are important aromatic secondary metabolites, are widely distributed
in plant foods. In this study, a simple, economical and fast on-line immobilized trypsin …

Evaluation of thrombin inhibitory activity of catechins by online capillary electrophoresis-based immobilized enzyme microreactor and molecular docking

QQ Li, FQ Yang, YZ Wang, ZY Wu, ZN Xia, H Chen - Talanta, 2018 - Elsevier
An online capillary electrophoresis (CE)-based thrombin (THR) immobilized enzyme
microreactor (IMER) method was established to screen THR inhibitors in this study. S-2366 …

Construction of enzyme-MOFs composite with carbon dots: A strategy to enhance the activity and increase the growth rate of the enzyme-ZIF-8 composite

M Wang, Y Chen, H Luo, M Wang, L Li, Z Xia… - International Journal of …, 2025 - Elsevier
Encapsulating enzymes in metal-organic frameworks (MOFs) enhances enzyme protection
and improves the accuracy of inhibitor recognition and screening. Zeolitic imidazolate …