Modeling Alzheimer's Disease in Caenorhabditis elegans

J Alvarez, P Alvarez-Illera, J Santo-Domingo… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …

Cannabidiol protects against Alzheimer's disease in C. elegans via ROS scavenging activity of its phenolic hydroxyl groups

Y Zhang, H Li, S Jin, Y Lu, Y Peng, L Zhao… - European journal of …, 2022 - Elsevier
Recent discoveries have implicated the potential of Cannabidiol (CBD) in the prevention of
Alzheimer's disease (AD). However, how CBD affects such neurodegenerative disorders …

Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease

N Kang, Y Luan, Y Jiang, W Cheng, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Rehmanniae Radix (RR, the dried tuberous roots of Rehmannia glutinosa (Gaertn.) DC.) is
an important traditional Chinese medicine distributed in Henan, Hebei, Inner Mongolia, and …

Hesperidin ameliorates amyloid-β toxicity and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans through acr-16 mediated activation of the …

S Kumar, PV Akhila, K Suchiang - Free Radical Biology and Medicine, 2023 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in aged
populations. Aberrant amyloid-beta accumulation is a common pathological feature in AD …

Insights into Pharmacological Activities of Nicotine and 6-Hydroxy-L-nicotine, a Bacterial Nicotine Derivative: A Systematic Review

RS Boiangiu, I Brinza, I Honceriu, M Mihasan, L Hritcu - Biomolecules, 2023 - mdpi.com
The purported cognitive benefits associated with nicotine and its metabolites in the brain are
a matter of debate. In this review, the impact of the pharmacologically active metabolite of a …

Silicon–Carbon Dots-Loaded Mesoporous Silica Nanocomposites (mSiO2@SiCDs): An Efficient Dual Inhibitor of Cu2+-Mediated Oxidative Stress and Aβ …

Q Li, X Yu, X Li, L Bao, Y Zhang, MJ Xie… - … Applied Materials & …, 2023 - ACS Publications
The redox-active metal ions, especially Cu2+, are highly correlated to Alzheimer's disease
(AD) by causing metal ion-mediated oxidative stress and toxic metal-bound β-amyloid (Aβ) …

A Ru 3+-functionalized-NMOF nanozyme as an inhibitor and disaggregator of β-amyloid aggregates

WC Luo, LN Bao, Y Zhang, ZT Zhang, X Li… - Journal of Materials …, 2024 - pubs.rsc.org
Alzheimer's disease (AD) heavily impacts human lives and is becoming serious as societies
age. Inhibiting and disaggregating β-amyloid aggregates is a possible solution for AD …

[HTML][HTML] Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE

VA Mitkevich, EP Barykin, S Eremina, B Pani… - Aging and …, 2023 - ncbi.nlm.nih.gov
The pathogenesis of Alzheimer's disease (AD) is associated with the formation of cerebral
amyloid plaques, the main components of which are the modified Aβ molecules as well as …

Role of lysocardiolipin acyltransferase in cigarette smoke-induced lung epithelial cell mitochondrial ROS, mitochondrial dynamics, and apoptosis

M Bandela, V Suryadevara, P Fu, SP Reddy… - Cell Biochemistry and …, 2022 - Springer
Cigarette smoke is the primary cause of Chronic Obstructive Pulmonary Disorder (COPD).
Cigarette smoke extract (CSE)-induced oxidative damage of the lungs results in …

Chiral carbon dots based on ternary carbon sources: a multifunctional therapeutic agent for Cu2+-induced Alzheimer's disease

L Bao, W Luo, Q Li, Y Zhang, Z Zhang, X Li, L Wang… - Carbon, 2024 - Elsevier
Metal dyshomeostasis is one of the pathological features of Alzheimer's disease (AD). Cu 2+
is believed to induce the formation of neurotoxic β-amyloid (Aβ) aggregates and aggravate …