Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome
J Zhang, W Lv, G Zhang, M Zeng, W Cao… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Metabolic syndrome (MetS) has become a major global public health problem
and there is an urgent need to elucidate its pathogenesis and find more effective targets and …
and there is an urgent need to elucidate its pathogenesis and find more effective targets and …
NRF2 in kidney physiology and disease
CD Bondi, HL Hartman, RJ Tan - Physiological Reports, 2024 - Wiley Online Library
The role of NRF2 in kidney biology has received considerable interest over the past decade.
NRF2 transcriptionally controls genes responsible for cellular protection against oxidative …
NRF2 transcriptionally controls genes responsible for cellular protection against oxidative …
[HTML][HTML] Interplay between the Redox System and Renal Tubular Transport
XL Wang, L Li, X Meng - Antioxidants, 2024 - mdpi.com
The kidney plays a critical role in maintaining the homeostasis of body fluid by filtration of
metabolic wastes and reabsorption of nutrients. Due to the overload, a vast of energy is …
metabolic wastes and reabsorption of nutrients. Due to the overload, a vast of energy is …
[HTML][HTML] Exogenous Ketones in Cardiovascular Disease and Diabetes: From Bench to Bedside
U Kansakar, C Nieves Garcia, G Santulli… - Journal of Clinical …, 2024 - mdpi.com
Ketone bodies are molecules produced from fatty acids in the liver that act as energy carriers
to peripheral tissues when glucose levels are low. Carbohydrate-and calorie-restricted diets …
to peripheral tissues when glucose levels are low. Carbohydrate-and calorie-restricted diets …
Mitochondrial-derived signaling mediates differentiation of parietal epithelial cells into podocytes
M Wang, W Wu, J Lu, R Lu, L Min, A Song… - Antioxidants & Redox …, 2024 - liebertpub.com
Aims: Parietal epithelial cells (PECs) are potential stem cells within the glomerulus,
migrating into site of podocyte loss to differentiate into podocytes. Little is known about the …
migrating into site of podocyte loss to differentiate into podocytes. Little is known about the …
Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes
The role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD)
progression remains unclear. In this study, we generated mice with renal tubule-specific …
progression remains unclear. In this study, we generated mice with renal tubule-specific …
Oxidative stress and NRF2 signaling in kidney injury
C Ng, M Kim, Yanti, MK Kwak - Toxicological Research, 2024 - Springer
Oxidative stress plays a crucial role in the pathogenesis of acute kidney injury (AKI), chronic
kidney disease (CKD), and the AKI-to-CKD transition. This review examines the intricate …
kidney disease (CKD), and the AKI-to-CKD transition. This review examines the intricate …
Dysregulation of lipid metabolism in chronic kidney disease and the role of natural products
YY Jiang, XL Jiang, HN Yu - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Dysregulation of lipid metabolism plays a key role in the onset and progression of CKD, and
a thorough understanding of its regulatory mechanisms is essential for the development of …
a thorough understanding of its regulatory mechanisms is essential for the development of …
[HTML][HTML] Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression
R Jin, Y Dai, Z Wang, Q Hu, C Zhang, H Gao, Q Yan - Biology, 2024 - mdpi.com
Chronic kidney disease (CKD) is a global health concern caused by conditions such as
hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural and …
hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural and …