Applications of gold nanoparticles in nanomedicine: recent advances in vaccines

SAC Carabineiro - Molecules, 2017 - mdpi.com
Nowadays, gold is used in (nano-) medicine, usually in the form of nanoparticles, due to the
solid proofs given of its therapeutic effects on several diseases. Gold also plays an important …

Multivalency in drug delivery–when is it too much of a good thing?

KC Tjandra, P Thordarson - Bioconjugate chemistry, 2019 - ACS Publications
Multivalency plays a large role in many biological and synthetic systems. The past 20 years
of research have seen an explosion in the study of multivalent drug delivery systems based …

DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation

X Huang, JZ Williams, R Chang, Z Li, CE Burnett… - Nature …, 2021 - nature.com
Biomaterials can improve the safety and presentation of therapeutic agents for effective
immunotherapy, and a high level of control over surface functionalization is essential for …

The protein corona as a confounding variable of nanoparticle-mediated targeted vaccine delivery

M Bros, L Nuhn, J Simon, L Moll, V Mailänder… - Frontiers in …, 2018 - frontiersin.org
Nanocarriers (NC) are very promising tools for cancer immunotherapy. Whereas
conventional vaccines are based on the administration of an antigen and an adjuvant in an …

Nanoparticulate immunotherapy for cancer

CH Kapadia, JL Perry, S Tian, JC Luft… - Journal of Controlled …, 2015 - Elsevier
Although surgery, radiation therapy, and chemotherapy have significantly improved as
treatments for cancer, they can rarely control metastatic disease and cures remain scarce …

Gold-based nanomaterials for applications in nanomedicine

S Ashraf, B Pelaz, P del Pino, M Carril… - … Systems for Applications …, 2016 - Springer
In this review, an overview of the current state-of-the-art of gold-based nanomaterials (Au
NPs) in medical applications is given. The unique properties of Au NPs, such as their …

[HTML][HTML] Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses

L Shen, S Tenzer, W Storck, D Hobernik… - Journal of Allergy and …, 2018 - Elsevier
Background Nanoparticle (NP)–based vaccines are attractive immunotherapy tools because
of their capability to codeliver antigen and adjuvant to antigen-presenting cells. Their cellular …

Antigen-specific immunotherapy for treatment of autoimmune liver diseases

N Richardson, STH Ng, DC Wraith - Frontiers in immunology, 2020 - frontiersin.org
The liver is a critical organ in controlling immune tolerance. In particular, it is now clear that
targeting antigens for presentation by antigen presenting cells in the liver can induce …

Combining antigen and immunomodulators: Emerging trends in antigen-specific immunotherapy for autoimmunity

L Northrup, MA Christopher, BP Sullivan… - Advanced drug delivery …, 2016 - Elsevier
A majority of current therapies for autoimmune diseases are general immunosuppressants,
which can compromise patient response to opportunistic infection and lead to adverse …

Precision synthesis of alternating copolymers via ring-opening polymerization of 1-substituted cyclobutenes

KA Parker, NS Sampson - Accounts of Chemical Research, 2016 - ACS Publications
Conspectus Investigation of complex molecular systems depends on our ability to correlate
physical measurements with molecular structure. Interpretation of studies that rely on …