Aptamer-related technologies represent a revolutionary advancement in the capacity to
rapidly develop new classes of targeting ligands. Structurally distinct RNA and DNA …

The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even
more difficult to decipher the pathophysiology to explain for the similarities and differences …

The sequencing of the human genome and the elucidation of many molecular pathways that
are important in disease have provided unprecedented opportunities for the development of …

RNA interference can be considered as an antisense mechanism of action that utilizes a
double-stranded RNase to promote hydrolysis of the target RNA. We have performed a …

Cytokines such as IL-1, tumour necrosis factor-alpha (TNF-α), IL-6 and IL-8 are increased in
inflamed colonic mucosa after administration of mouse DSS. Nuclear factor κ B (NF-κ B) is a …

The mechanisms underlying the chronic intestinal inflammation that is a hallmark of
inflammatory bowel diseases (IBD) are complex. Components of the pathological response …

Antisense technology exploits oligonucleotide analogs to bind to target RNAs via Watson-
Crick hybridization. Once bound, the antisense agent either disables or induces the …

Given the progress reported during the past decade, a wide range of chemical modifications
may be incorporated into potential antisense drugs. These modifications may influence all …

Several molecular technologies aimed at regulating gene expression that have been
recently developed as a strategy to combat inflammatory and neoplastic diseases. Among …

Abbreviations: AP-1, activation protein-1; CAM, cell adhesion molecule; ESL, E-selectin
ligand; ICAM, intercellular adhesion molecule; IL, interleukin; mAb, monoclonal antibody; NF …