Methylmercury and brain development: A review of recent literature

AA Dos Santos, MA Hort, M Culbreth… - Journal of trace …, 2016 - Elsevier
Methylmercury (MeHg) is a potent environmental pollutant, which elicits significant toxicity in
humans. The central nervous system (CNS) is the primary target of toxicity, and is …

Advances on the influence of methylmercury exposure during neurodevelopment

J Pan, X Li, Y Wei, L Ni, B Xu, Y Deng… - Chemical Research …, 2022 - ACS Publications
Mercury (Hg) is a toxic heavy-metal element, which can be enriched in fauna and flora and
transformed into methylmercury (MeHg). MeHg is a widely distributed environmental …

Mercury toxicity and neurogenesis in the mammalian brain

LC Abbott, F Nigussie - International Journal of Molecular Sciences, 2021 - mdpi.com
The mammalian brain is formed from billions of cells that include a wide array of neuronal
and glial subtypes. Neural progenitor cells give rise to the vast majority of these cells during …

Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight

FY Nisa, MA Rahman, MA Hossen, MF Khan… - Annals of …, 2021 - Taylor & Francis
Alzheimer's disease (AD) is the most conspicuous chronic neurodegenerative syndrome,
which has become a significant challenge for the global healthcare system. Multiple studies …

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

A Nishimura, K Shimoda, T Tanaka, T Toyama… - Science …, 2019 - science.org
Chronic exposure to methylmercury (MeHg), an environmental electrophilic pollutant,
reportedly increases the risk of human cardiac events. We report that exposure to a low, non …

[HTML][HTML] Post-translational modifications in MeHg-induced neurotoxicity

T Ke, FM Gonçalves, CL Gonçalves… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Mercury (Hg) exposure remains a major public health concern due to its widespread
distribution in the environment. Organic mercurials, such as MeHg, have been extensively …

Site-specific neural hyperactivity via the activation of MAPK and PKA/CREB pathways triggers neuronal degeneration in methylmercury-intoxicated mice

M Fujimura, F Usuki - Toxicology letters, 2017 - Elsevier
Methylmercury (MeHg) induces site-specific neurotoxicity in the adult brain. In this study, we
investigated the site-specific expression of the signaling cascade related to neural activity in …

Methylmercury augments Nrf2 activity by downregulation of the Src family kinase Fyn

M Culbreth, Z Zhang, M Aschner - Neurotoxicology, 2017 - Elsevier
Methylmercury (MeHg) is a potent developmental neurotoxicant that induces an oxidative
stress response in the brain. It has been demonstrated that MeHg exposure increases …

Effects of low doses of methylmercury (MeHg) exposure on definitive endoderm cell differentiation in human embryonic stem cells

B Li, X Jin, HM Chan - Archives of Toxicology, 2023 - Springer
Fetal development is one of the most sensitive windows to methylmercury (MeHg) toxicity.
Laboratory and epidemiological studies have shown a dose–response relationship between …

Single cell RNA sequencing detects persistent cell type-and methylmercury exposure paradigm-specific effects in a human cortical neurodevelopmental model

MD Neely, S Xie, LM Prince, H Kim, AM Tukker… - Food and Chemical …, 2021 - Elsevier
The developing human brain is uniquely vulnerable to methylmercury (MeHg) resulting in
lasting effects especially in developing cortical structures. Here we assess by single-cell …