Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

Muscle paralysis after spinal cord injury is partly caused by a loss of brainstem-derived
serotonin (5-HT), which normally maintains motoneuron excitability by regulating crucial …

All movements are generated by the activation of motoneurons, and hence their input-output
properties define the final step in processing of all motor commands. A major challenge to …

Hyperexcitability has been suggested to contribute to motoneuron degeneration in
amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a …

The excitability of spinal motoneurons is both fundamental for motor behavior and essential
in diagnosis of neural disorders. There are two mechanisms for altering this excitability. The …

Persistent inward currents (PICs) are present in many types of neurons and likely have
diverse functions. In spinal motoneurons, PICs are especially strong, primarily located in …

It is now accepted that neurons contain and release multiple transmitter substances.
However, we still have only limited insight into the regulation and functional effects of this co …

The state of areflexia and muscle weakness that immediately follows a spinal cord injury
(SCI) is gradually replaced by the recovery of neuronal and network excitability, leading to …

COLLINS, DF Central contributions to contractions evoked by tetanic neuromuscular
electrical stimulation. Exerc. Sport Sci. Rev., Vol. 35, No. 3, pp. 102Y109, 2007. Tetanic …