For vascular remodeling in hypertension, it is essential that vascular smooth muscle cells
(VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs …

Alzheimer's disease (AD) is the most common (60% to 80%) age‐related disease
associated with dementia and is characterized by a deterioration of behavioral and cognitive …

Background Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied
during the 'preclinical'stage (pathology present with cognition intact) before severe neuronal …

A close association between pericytes and endothelial cells (ECs) is crucial to the stability
and function of capillary blood vessels and microvessels. The loss or dysfunction of …

The excessive extracellular accumulation of glutamate in the ischemic brain leads to an
overactivation of glutamate receptors with consequent excitotoxic neuronal death. Neuronal …

Abnormal activation of calpain is implicated in synaptic dysfunction and participates in
neuronal death in Alzheimer disease (AD) and other neurological disorders …

Background—Although dysfunction of VE-cadherin–mediated adherence junctions in
vascular endothelial cells (ECs) is thought to be one of the initial steps of atherosclerosis …

Time-dependent changes in blood-based protein biomarkers can help identify the
pathological processes in blast-induced traumatic brain injury (bTBI), assess injury severity …

Muscle atrophy is an inevitable sequel of fasting, denervation, aging, exposure to
microgravity, and many human diseases including, cancer, type-2 diabetes, and renal …

Calpain is defined as a member of the superfamily of cysteine proteases possessing the
CysPC motif within the gene. Calpain-1 and-2, which are categorized as conventional …