A new series of quinoline derivatives has been designed and synthesized as probable
protease inhibitors (PIs) against severe acute respiratory syndrome coronavirus 2. In silico …

As a highly prevalent disease among women worldwide, breast cancer remains in urgent
need of further elucidation its molecular mechanisms to improve the patient outcomes …

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Despite causing great
social and economic impact, there is currently no cure for AD. The most effective therapy to …

Single-nucleotide polymorphisms (SNPs) are the most common genetic variations for
various complex human diseases, including cancers. Genome-wide association studies …

Centromere protein I (CENPI), an important member of centromere protein family, has been
suggest to serve as a oncogene in breast cancer, but the clinical significance and biological …

Human kinases play essential and diverse roles in the cellular activities of maintaining
homeostasis and growth. Genetic mutations in the genes encoding the kinases (or …

Integrative Bioinformatics analysis helps to explore various mechanisms of Nitroglycerin
activity in different types of cancers and help predict target genes through which …

Aims In order to explore the etiology of gastric cancer on global gene expression level, we
developed advanced bioinformatic analysis to investigate the variations of global gene …

Purpose Breast cancer (BC) remains a serious health threat for women due to its high
incidence and the trend of rejuvenation. Accumulating evidence has highlighted that …

Background Centromere protein I (CENPI) has been shown to affect the tumorigenesis of
breast and colorectal cancers. However, its biological role and prognostic value in other …