Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of
the‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites …

Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

Introduction Metabolomics has become a crucial part of systems biology; however, data
analysis is still often undertaken in a reductionist way focusing on changes in individual …

NMR measures a relatively small portion of the human metabolome, which roughly
corresponds to all free small molecules present in concentrations≥ 1 μM. However, the …

Sample size determination is a fundamental step in the design of experiments. Methods for
sample size determination are abundant for univariate analysis methods, but scarce in the …

In the era of precision medicine, the analysis of simple information like sex and age can
increase the potential to better diagnose and treat conditions that occur more frequently in …

Discovery of novel biomarkers is critical for early diagnosis of acute coronary syndrome
(ACS). Serum metabolite profiling of ST-elevation myocardial infarction (STEMI), unstable …

“A Mathematical Theory of Communication” was published in 1948 by Claude Shannon to
address the problems in the field of data compression and communication over (noisy) …

Bariatric surgery is currently one of the most effective treatments for obesity and leads to
significant weight reduction, improved cardiovascular risk factors and overall survival in …

Blood is one of the most used biofluids in metabolomics studies, and the serum and plasma
fractions are routinely used as a proxy for blood itself. Here we investigated the association …