Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

The pandemic of COVID-19, caused by the coronavirus, SARS-CoV-2, has had a global
impact not seen for an infectious disease for over a century. This acute pandemic has …

Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the
most significant changes in human evolution, with far-reaching consequences for the …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Over 650 million adults are obese (body mass index≥ 30 kg/m2) worldwide. Obesity is
commonly associated with several comorbidities, including cardiovascular disease and type …

Background Genome-wide association studies of Alzheimer's disease (AD) have implicated
pathways related to lipid homeostasis and innate immunity in AD pathophysiology …

Increased adipose tissue macrophages (ATMs) correlate with metabolic dysfunction in
humans and are causal in development of insulin resistance in mice. Recent bulk and single …

Dysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes
(DM) but underlying mechanisms remain unclear. Our objective in this discovery analysis …

Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse
roles in the control of cellular processes that go beyond the control of cholesterol …

Maternal obesity adversely impacts the in utero metabolic environment, but its effect on fetal
hematopoiesis remains incompletely understood. During late development, the fetal bone …