[HTML][HTML] Cell microencapsulation technologies for sustained drug delivery: Latest advances in efficacy and biosafety

TB Lopez-Mendez, E Santos-Vizcaino… - Journal of Controlled …, 2021 - Elsevier
The development of cell microencapsulation systems began several decades ago. However,
today few systems have been tested in clinical trials. For this reason, in the last years …

Magnetic retrieval of encapsulated Beta cell transplants from diabetic mice using dual‐function MRI visible and retrievable microcapsules

D Delcassian, I Luzhansky, V Spanoudaki… - Advanced …, 2020 - Wiley Online Library
Encapsulated beta cell transplantation offers a potential cure for a subset of diabetic
patients. Once transplanted, beta cell grafts can help to restore glycemic control; however …

99mTc-linezolid as a radiotracer for brain abscess: labeling, in silico docking, and biodistribution studies

OA El-Kawy, IT Ibrahim, HA Shweeta… - Applied Radiation and …, 2023 - Elsevier
Brain abscess is a life-threatening condition that requires a timely and accurate diagnosis. In
this study, linezolid, an oxazolidinone antibiotic, was labeled with technetium-99m according …

Radioiodination, nasal nanoformulation and preliminary evaluation of isovanillin: a new potential brain cancer-targeting agent

OA El-Kawy, HA Shweeta, KM Attallah - Applied Radiation and Isotopes, 2022 - Elsevier
Brain cancer is a challenging disease to treat using conventional approaches. The present
investigation aimed to develop a radiopharmaceutical targeting brain cancer based on …

Preparation and evaluation of radiolabeled gliclazide parenteral nanoemulsion as a new tracer for pancreatic β-cells mass

OA El-Kawy, IT Ibrahim, HA Shewatah… - International Journal of …, 2023 - Taylor & Francis
Purpose The present investigation aims to develop and evaluate a radiopharmaceutical for
targeting and assessing β-cells mass based on gliclazide, an antidiabetic drug that …

Radiolabeling, characterization, and preclinical evaluation of plazomicin: A potential tracer for bacterial infection

OA El‐kawy, G Abdelaziz… - Chemical Biology & …, 2022 - Wiley Online Library
In this study, 99mTc–plazomicin, a new radio‐antibiotic complex, was prepared specifically
for bacterial infection localization and monitoring. Factors affecting the labeling reaction …

Preparation and evaluation of 99mTc-anidulafungin: a potential radiotracer for fungal infection

OA El-Kawy, MS Sayed, AS Abdel-Razek - Journal of Radioanalytical and …, 2020 - Springer
Aiming to develop specific diagnostic tool for invasive fungal infection, a
radiopharmaceutical based on anidulafungin was investigated. A two-step approach was …

Quantifying AMPARs with 99mTc-omberacetam: a novel diagnostic radiotracer for ischemic stroke

HF Azhari, AM Hashem - Journal of Umm Al-Qura University for Applied …, 2024 - Springer
Synaptic trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
(AMPARs) is thought to cause excitotoxicity brain ischemia. However, given the current …

Preparation and evaluation of radiolabeled acetaminosalol microspheres: A new potential selective radiotracer for ulcerative colitis early diagnosis

OA El‐Kawy, HA Shweeta… - Journal of Labelled …, 2024 - Wiley Online Library
Acetaminosalol labeling reaction with technetium‐99m was optimized, and the
radiocomplex was obtained in a high radiochemical yield of 98.9±0.6% and high stability (> …

Radiolabeling and evaluation of fonturacetam hydrazide as a radiotracer for visualization of brain function

OA El-Kawy, HA Shweeta, KM Sallam - Journal of Radioanalytical and …, 2023 - Springer
Abstract [99mTc] fonturacetam hydrazide was radiosynthesized to assess neuropsychiatric
disorders by targeting the brain. The nootropic drug was labeled with technetium-99m, and …