Recent updates on phytoconstituent alpha-glucosidase inhibitors: An approach towards the treatment of type two diabetes

H Kashtoh, KH Baek - Plants, 2022 - mdpi.com
Diabetes is a common metabolic disorder marked by unusually high plasma glucose levels,
which can lead to serious consequences such as retinopathy, diabetic neuropathy and …

Nutritional and medicinal plants as potential sources of enzyme inhibitors toward the bioactive functional foods: an updated review

H Saleem, A Yaqub, R Rafique… - Critical Reviews in …, 2024 - Taylor & Francis
Enzymes are biologically active complex protein molecules that catalyze most chemical
reactions in living organisms, and their inhibitors accelerate biological processes. This …

Chemical composition, antioxidant, and anti-diabetic activities of ethyl acetate fraction of Stachys riederi var. japonica (Miq.) in streptozotocin-induced type 2 diabetic …

K Saravanakumar, S Park, AVA Mariadoss… - Food and Chemical …, 2021 - Elsevier
This work analysed the chemical composition, antioxidant, and enzyme inhibitory activities
of solvent extract (SJ-ME) and fractions (SJ-HF, SJ-EAF, and SJ-MF) of the Stachys riederi …

In Vitro Alpha-Amylase and Alpha-Glucosidase Inhibitory Activity and In Vivo Antidiabetic Activity of Withania frutescens L. Foliar Extract

H Mechchate, I Es-Safi, A Louba, AS Alqahtani… - Molecules, 2021 - mdpi.com
Withania frutescens L. is a wild perennial woody plant used by the local population for
diverse therapeutic purposes. This work aims to study for the first time the potential inhibitory …

Molecular dynamics simulation and pharmacokinetics studies of ombuin and quercetin against human pancreatic α-amylase

B Kikiowo, I Ahmad, AA Alade, T T. Ijatuyi… - Journal of …, 2023 - Taylor & Francis
Diabetes mellitus (DM) is a group of metabolic disorders characterised by chronic
hyperglycaemia. DM is currently one of the top ten causes of death in humans. Chronic …

Phytochemical Characterization, Functional Nutrition, and Anti-Diabetic Potentials of Leptadenia hastata (pers) Decne Leaves: In Silico and In Vitro Studies

IF Chukwuma, FN Nworah, VO Apeh… - … and Biology Insights, 2022 - journals.sagepub.com
The geometrical increase in diabetes mellitus (DM) and the undesirable side effects of
synthetic drugs have intensified efforts to search for an effective and safe anti-diabetic …

Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth

OM Ogunyemi, GA Gyebi, A Saheed, J Paul… - Frontiers in molecular …, 2022 - frontiersin.org
Alpha-amylase is widely exploited as a drug target for preventing postprandial
hyperglycemia in diabetes and other metabolic diseases. Inhibition of this enzyme by plant …

The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review

NNH Nik Salleh, FA Othman, NA Kamarudin, SC Tan - Molecules, 2020 - mdpi.com
In Southeast Asia, traditional medicine has a longestablished history and plays an important
role in the health care system. Various traditional medicinal plants have been used to treat …

Molecular Docking and Dynamics Simulation of Natural Compounds from Betel Leaves (Piper betle L.) for Investigating the Potential Inhibition of Alpha-Amylase and …

S Ahmed, MC Ali, RA Ruma, S Mahmud, GK Paul… - Molecules, 2022 - mdpi.com
Piper betle L. is widely distributed and commonly used medicinally important herb. It can
also be used as a medication for type 2 diabetes patients. In this study, compounds of P …

Complexation of starch and phenolic compounds during food processing and impacts on the release of phenolic compounds

R Wang, M Li, MA Brennan, S Dhital… - … Reviews in Food …, 2023 - Wiley Online Library
Phenolic compounds can form complexes with starch during food processing, which can
modulate the release of phenolic compounds in the gastrointestinal tract and regulate the …