Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

SC Dyall - Frontiers in aging neuroscience, 2015 - frontiersin.org
Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and
represent a potential treatment for a variety of neurodegenerative and neurological …

Proresolving lipid mediators and mechanisms in the resolution of acute inflammation

CD Buckley, DW Gilroy, CN Serhan - Immunity, 2014 - cell.com
Inflammatory responses, like all biological cascades, are shaped by a delicate balance
between positive and negative feedback loops. It is now clear that in addition to positive and …

Lipid mediators in the resolution of inflammation

CN Serhan, N Chiang, J Dalli… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

CN Serhan, J Dalli, RA Colas, JW Winkler… - Biochimica et Biophysica …, 2015 - Elsevier
Acute inflammatory responses are protective, yet without timely resolution can lead to
chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self …

How does high DHA fish oil affect health? A systematic review of evidence

S Ghasemi Fard, F Wang, AJ Sinclair… - Critical reviews in …, 2019 - Taylor & Francis
The health benefits of fish oil, and its omega-3 long chain polyunsaturated fatty acid content,
have attracted much scientific attention in the last four decades. Fish oils that contain higher …

DHA-and EPA-derived resolvins, protectins, and maresins in airway inflammation

MG Duvall, BD Levy - European journal of pharmacology, 2016 - Elsevier
Essential fatty acids can serve as important regulators of inflammation. A new window into
mechanisms for the resolution of inflammation was opened with the identification and …

A novel anti-inflammatory role of omega-3 PUFAs in prevention and treatment of atherosclerosis and vascular cognitive impairment and dementia

M Simonetto, M Infante, RL Sacco, T Rundek… - Nutrients, 2019 - mdpi.com
Atherosclerosis is an inflammatory chronic disease affecting arterial vessels and leading to
vascular diseases, such as stroke and myocardial infarction. The relationship between …

Novel n-3 immunoresolvents: structures and actions

J Dalli, RA Colas, CN Serhan - Scientific reports, 2013 - nature.com
Resolution of inflammation is now held to be an active process where autacoids promote
homeostasis. Using functional-metabololipidomics and in vivo systems, herein we report that …

Lipidomics of human brain aging and Alzheimer's disease pathology

A Naudí, R Cabré, M Jové, V Ayala, H Gonzalo… - International review of …, 2015 - Elsevier
Lipids stimulated and favored the evolution of the brain. Adult human brain contains a large
amount of lipids, and the largest diversity of lipid classes and lipid molecular species …

Unesterified docosahexaenoic acid is protective in neuroinflammation

SK Orr, S Palumbo, F Bosetti, HT Mount… - Journal of …, 2013 - Wiley Online Library
Abstract Docosahexaenoic acid (22: 6n‐3) is the major brain n‐3 polyunsaturated fatty acid
and it is possible that docosahexaenoic acid is anti‐inflammatory in the brain as it is known …