Epithelial-mesenchymal transition in tissue repair and fibrosis

RC Stone, I Pastar, N Ojeh, V Chen, S Liu… - Cell and tissue …, 2016 - Springer
The epithelial-mesenchymal transition (EMT) describes the global process by which
stationary epithelial cells undergo phenotypic changes, including the loss of cell-cell …

Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis

I Fabregat, D Caballero-Díaz - Frontiers in oncology, 2018 - frontiersin.org
The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

TGF‐β signalling and liver disease

I Fabregat, J Moreno‐Càceres, A Sánchez… - The FEBS …, 2016 - Wiley Online Library
The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

Signaling mechanisms of the epithelial-mesenchymal transition

DM Gonzalez, D Medici - Science signaling, 2014 - science.org
The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic
development and tissue repair. EMT also contributes to the progression of disease …

TGF-β in progression of liver disease

S Dooley, P Ten Dijke - Cell and tissue research, 2012 - Springer
Transforming growth factor-β (TGF-β) is a central regulator in chronic liver disease
contributing to all stages of disease progression from initial liver injury through inflammation …

Epithelial–mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways

L Larue, A Bellacosa - Oncogene, 2005 - nature.com
Epithelial–mesenchymal transition (EMT) is an important process during development by
which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced …

Mechanisms of the epithelial–mesenchymal transition by TGF-β

MK Wendt, TM Allington, WP Schiemann - Future Oncology, 2009 - Taylor & Francis
The formation of epithelial cell barriers results from the defined spatiotemporal differentiation
of stem cells into a specialized and polarized epithelium, a process termed mesenchymal …

Epithelial–mesenchymal transition in hepatocellular carcinoma

F Van Zijl, G Zulehner, M Petz, D Schneller… - Future …, 2009 - Taylor & Francis
The transition of epithelial cells to a mesenchymal phenotype is of paramount relevance for
embryonic development and adult wound healing. During the past decade, the epithelial …

EGFR signaling promotes TGFβ-dependent renal fibrosis

J Chen, JK Chen, K Nagai, D Plieth, M Tan… - Journal of the …, 2012 - journals.lww.com
The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain
incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF …

Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression

MK Wendt, M Tian, WP Schiemann - Cell and tissue research, 2012 - Springer
Transforming growth factor-β (TGF-β) is a potent pleiotropic cytokine that regulates
mammalian development, differentiation, and homeostasis in essentially all cell types and …