Spine biomechanical testing methodologies: the controversy of consensus vs scientific evidence

JJ Costi, EH Ledet, GD O'Connell - JOR spine, 2021 - Wiley Online Library
Biomechanical testing methodologies for the spine have developed over the past 50 years.
During that time, there have been several paradigm shifts with respect to techniques. These …

Guidelines for ex vivo mechanical testing of tendon

SP Lake, JG Snedeker, VM Wang… - Journal of …, 2023 - Wiley Online Library
Tendons are critical for the biomechanical function of joints. Tendons connect muscles to
bones and allow for the transmission of muscle forces to facilitate joint motion. Therefore …

Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues

JL Zitnay, GS Jung, AH Lin, Z Qin, Y Li, SM Yu… - Science …, 2020 - science.org
Overuse injuries to dense collagenous tissues are common, but their etiology is poorly
understood. The predominant hypothesis that micro-damage accumulation exceeds the rate …

Water-content related alterations in macro and micro scale tendon biomechanics

PF Lozano, M Scholze, C Babian, H Scheidt… - Scientific reports, 2019 - nature.com
Though it is known that the water content of biological soft tissues alters mechanical
properties, little attempt has been made to adjust the tissue water content prior to …

[HTML][HTML] Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix

MS Godinho, CT Thorpe, SE Greenwald, HRC Screen - Acta biomaterialia, 2021 - Elsevier
The tendon interfascicular matrix (IFM) binds tendon fascicles together. As a result of its low
stiffness behaviour under small loads, it enables non-uniform loading and increased overall …

Aponeurosis structure-function properties: Evidence of heterogeneity and implications for muscle function

BB Wheatley, OL Dyer, EE Tully, MA Seeley - Acta Biomaterialia, 2023 - Elsevier
Aponeurosis is a sheath-like connective tissue that aids in force transmission from muscle to
tendon and can be found throughout the musculoskeletal system. The key role of …

[HTML][HTML] The dispersion of viscoelastic properties of fascicle bundles within the tendon results from the presence of interfascicular matrix and flow of body fluids

A Mlyniec, S Dabrowska, M Heljak, WP Weglarz… - Materials Science and …, 2021 - Elsevier
In this work, we investigate differences in the mechanical and structural properties of tendon
fascicle bundles dissected from different areas of bovine tendons. The properties of tendon …

Saline-polyethylene glycol blends preserve in vitro annulus fibrosus hydration and mechanics: An experimental and finite-element analysis

B Werbner, M Zhou, N McMindes, A Lee, M Lee… - Journal of the …, 2022 - Elsevier
Precise control of tissue water content is essential for ensuring accurate, repeatable, and
physiologically relevant measurements of tissue mechanics and biochemical composition …

Tendon multiscale structure, mechanics, and damage are affected by osmolarity of bath solution

ET Bloom, AH Lee, DM Elliott - Annals of biomedical engineering, 2021 - Springer
One of the most common bath solutions used in musculoskeletal mechanical testing is
phosphate buffered saline (PBS). In tendon, swelling induced by physiological PBS results …

Non-enzymatic glycation of annulus fibrosus alters tissue-level failure mechanics in tension

B Werbner, M Lee, A Lee, L Yang, M Habib… - Journal of the …, 2022 - Elsevier
Advanced-glycation end products (AGEs) are known to accumulate in biological tissues with
age and at an accelerated rate in patients with diabetes and chronic kidney disease …