Liver cancer is one of the most frequent tumor entities worldwide, which is causally linked to
viral infection, fatty liver disease, life-style factors and food-borne carcinogens, particularly …

Myopia is becoming more common across the world, necessitating the development of
preventive methods. We investigated the activity of early growth response 1 (EGR-1) protein …

Mutation spectra and mutational signatures in cancerous and non-cancerous tissues can be
identified by various established techniques of massively parallel sequencing (or next …

Methyleugenol (ME), found in numerous plants and spices, is a rodent carcinogen and is
classified as “possibly carcinogenic to humans”. The hypothesis of a carcinogenic risk for …

Simple Summary To identify potential genetic markers for evaluating hypermutated cancers,
we investigated driver mutations, mutational signatures, tumor-associated neoantigens, and …

The liver is a central organ for detoxification of xenobiotics and other important functions.
This chapter describes the existing models for hepatic and pancreatic human diseases and …

Recent years have witnessed an expansion of mutagenesis research focusing on
experimentally modeled genome-scale mutational signatures of carcinogens and of …

Historically, environmental chemical/drug toxicity risk assessment has employed very similar
approaches to characterizing risk despite often having differences in degrees of tolerance to …

Historically, environmental chemical/drug toxicity risk assessment has employed very similar
approaches to characterizing risk despite often having differences in degrees of tolerance to …