Abstract The ClusPro server (https://cluspro. org) is a widely used tool for protein–protein
docking. The server provides a simple home page for basic use, requiring only two files in …

Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via
the cholinergic anti-inflammatory pathway and are expressed in microglia, the brain's …

It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are
distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP …

Abstract Glycine Receptors (GlyRs) provide inhibitory neuronal input in the spinal cord and
brainstem, which is critical for muscle coordination and sensory perception. Synaptic GlyRs …

The intracellular domain (ICD) of Cys-loop receptors mediates diverse functions. To date, no
structure of a full-length ICD is available due to challenges stemming from its dynamic …

Ethanol alters nerve signalling by interacting with proteins in the central nervous system,
particularly pentameric ligand-gated ion channels. A recent series of mutagenesis …

In recent years there has been an increase in the understanding of ethanol actions on the
type A γ-aminobutyric acid chloride channel (GABAAR), a member of the pentameric ligand …

It is well accepted that ethanol is able to produce major health and economic problems
associated to its abuse. Because of its intoxicating and addictive properties, it is necessary …

Key points The nucleus accumbens (nAc) is involved in addiction‐related behaviour caused
by several drugs of abuse, including alcohol. Glycine receptors (GlyRs) are potentiated by …

Alcohol abuse and alcoholism are major health problems and one of the leading
preventable causes of death. Before achieving better treatments for alcoholism, it is …