Herein we summarize important discoveries made over many years about Leydig cell
function and regulation. Fetal Leydig cells produce the high levels of androgen (testosterone …

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the
steroidogenic cells of the adrenal, gonad, placenta and brain contain the cholesterol side …

Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

BACKGROUND Obesity has now been recognized as a high-risk factor for reproductive
health. Although remarkable advancements have been made in ART, a considerable …

Steroid hormones regulate diverse physiological functions such as reproduction, blood salt
balance, maintenance of secondary sexual characteristics, response to stress, neuronal …

The corpus luteum (CL) is one of the few endocrine glands that forms from the remains of
another organ and whose function and survival are limited in scope and time. The CL is the …

The transfer of cholesterol from the outer to the inner mitochondrial membrane is the rate-
limiting step in hormone-induced steroid formation. To ensure that this step is achieved …

Steroidogenesis begins with cellular internalization of low-density lipoprotein particles and
subsequent intracellular processing of cholesterol. Disorders in these steps include …

▪ Abstract Ovulation is a complex process that is initiated by the lutenizing hormone surge
and is controlled by the temporal and spatial expression of specific genes. This review …