Simple Summary Melanoma is a skin cancer with a high mortality and a dramatically rising
presence worldwide. Recent research has shed new light on the genetic events that …

Simple Summary Precision oncology is emerging as a viable option to improve survival in
patients who fail to remain disease-free even after the employment of currently available …

Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma.
Despite a good prognosis, approximately a quarter of PTC patients are likely to relapse …

The success of gene therapy depends largely on the development of gene vectors and
effective gene delivery systems. It has been demonstrated that cationic microbubbles can be …

PTEN encodes a tumor suppressor with lipid and protein phosphatase activities whose
dysfunction has been implicated in melanomagenesis; less is known about how its …

Targeting mutant BRAF in patients with melanomas harboring this oncogene has been
highly successful as a first-line treatment, but other mutations may affect its efficacy and alter …

Simple Summary Skin cancer, such as melanoma, is often treatable but becomes deadly
when it expands to other places in the body, a process called metastasis. While many …

Simple Summary One of the hallmarks of cancer is increased cellular proliferation; therefore,
many therapeutic strategies aim at arresting cellular division. Several chemotherapeutic …

Over the last decades, research has focused on the role of pleckstrin homology (PH) domain
leucine-rich repeat protein phosphatases (PHLPPs) in regulating cellular signaling via …

Objective Colon cancer (CC) is the third most common cancer with a high rate of incidence
and mortality. Therefore, it is highly necessary to explore novel targets of CC. Methods The …