Thrombolytic therapies for ischemic stroke: Triumphs and future challenges

A Moussaddy, AM Demchuk, MD Hill - Neuropharmacology, 2018 - Elsevier
Acute stroke therapy has significantly evolved over the last two decades. The two main
advances have been the approval of intravenous chemical thrombolysis in 1995, and the …

Blood–brain barrier leakage and hemorrhagic transformation: The Reperfusion Injury in Ischemic StroKe (RISK) study

F Arba, B Piccardi, V Palumbo, S Biagini… - European Journal of …, 2021 - Wiley Online Library
Background and purpose In patients with acute ischemic stroke treated with reperfusion
therapy we aimed to evaluate whether pretreatment blood–brain barrier (BBB) leakage is …

Neuroimaging prediction of hemorrhagic transformation for acute ischemic stroke

L Hong, TM Hsu, Y Zhang, X Cheng - Cerebrovascular Diseases, 2022 - karger.com
Background: Hemorrhagic transformation (HT) is a common complication of acute ischemic
stroke, often resulting from reperfusion therapy. Early prediction of HT can enable stroke …

Reperfusion within 6 hours outperforms recanalization in predicting penumbra salvage, lesion growth, final infarct, and clinical outcome

TH Cho, N Nighoghossian, IK Mikkelsen, L Derex… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—The relative merits of reperfusion versus recanalization to
predict tissue and clinical outcomes in anterior circulation stroke have been previously …

Local spatio-temporal encoding of raw perfusion MRI for the prediction of final lesion in stroke

M Giacalone, P Rasti, N Debs, C Frindel, TH Cho… - Medical image …, 2018 - Elsevier
We address the medical image analysis issue of predicting the final lesion in stroke from
early perfusion magnetic resonance imaging. The classical processing approach for the …

[HTML][HTML] Reperfusion of very low cerebral blood volume lesion predicts parenchymal hematoma after endovascular therapy

NK Mishra, S Christensen, A Wouters, BCV Campbell… - Stroke, 2015 - journals.lww.com
Ischemic stroke patients with regional very low cerebral blood volume (VLCBV) on baseline
imaging have increased risk of parenchymal hemorrhage (PH) after intravenous alteplase …

Crossed cerebellar diaschisis in acute ischemic stroke: impact on morphologic and functional outcome

WG Kunz, WH Sommer, C Höhne… - Journal of Cerebral …, 2017 - journals.sagepub.com
Crossed cerebellar diaschisis (CCD) is the phenomenon of hypoperfusion and
hypometabolism of the contralateral cerebellar hemisphere caused by dysfunction of the …

Interaction of recanalization, intracerebral hemorrhage, and cerebral edema after intravenous thrombolysis

BK Cheripelli, X Huang, R MacIsaac, KW Muir - Stroke, 2016 - Am Heart Assoc
Background and Purpose—Both intracerebral hemorrhage (ICH) and brain edema have
been attributed to reperfusion after intravenous thrombolysis. We explored the interaction of …

Predicting Collateral Status With Magnetic Resonance Perfusion Parameters: Probabilistic Approach With a Tmax-Derived Prediction Model

MJ Lee, JP Son, SJ Kim, S Ryoo, SY Woo, J Cha… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—Good collateral flow is an important predictor for favorable
responses to recanalization therapy and successful outcomes after acute ischemic stroke …

Multiparametric magnetic resonance imaging for prediction of parenchymal hemorrhage in acute ischemic stroke after reperfusion therapy

K Nael, JR Knitter, R Jahan, J Gornbein, Z Ajani… - Stroke, 2017 - Am Heart Assoc
Background and Purpose—Patients with acute ischemic stroke are at increased risk of
developing parenchymal hemorrhage (PH), particularly in the setting of reperfusion …