Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …

Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

The vitamins are a chemically disparate group of compounds whose only common feature is
that they are dietary essentials that are required in small amounts for the normal functioning …

Since the beginning of the last century, seminal discoveries have identified pyridine
nucleotides as the major redox carriers in all organisms. Recent research has unravelled an …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a widespread and potent calcium-
mobilizing messenger that is highly unusual in activating calcium channels located on acidic …

Lysosomes have traditionally been viewed as degradative organelles, although a growing
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …

Vascular endothelial growth factor (VEGF) and its receptors VEGFR1/VEGFR2 play major
roles in controlling angiogenesis, including vascularization of solid tumors. Here we …

Two-pore channels (TPCs) are evolutionarily important members of the voltage-gated ion
channel superfamily. TPCs localize to acidic Ca2+ stores within the endolysosomal system …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating
the release of intracellular Ca 2+ required for many essential cellular processes. Recent …

Accumulating evidence implicates acidic organelles of the endolysosomal system as
mobilisable stores of Ca2+ but their relationship to the better-characterised endoplasmic …