Actin dynamics, architecture, and mechanics in cell motility
L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …
drives a large range of cellular processes including polarity establishment, morphogenesis …
Actin assembly mechanisms at a glance
The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …
establishing the astonishing morphological diversity and dynamics of mammalian cells …
pH sensing and regulation in cancer
Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …
1, 6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities
R Düster, IH Kaltheuner, M Schmitz, M Geyer - Journal of Biological …, 2021 - ASBMB
The concept of liquid–liquid phase separation (LLPS) has emerged as an intriguing
mechanism for the organization of membraneless compartments in cells. The alcohol 1, 6 …
mechanism for the organization of membraneless compartments in cells. The alcohol 1, 6 …
Actin on and around the Nucleus
PM Davidson, B Cadot - Trends in Cell Biology, 2021 - cell.com
Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …
Formins as effector proteins of Rho GTPases
S Kühn, M Geyer - Small GTPases, 2014 - Taylor & Francis
Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …
The formin inhibitor SMIFH2 inhibits members of the myosin superfamily
Y Nishimura, S Shi, F Zhang, R Liu… - Journal of cell …, 2021 - journals.biologists.com
The small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell
biological studies. It inhibits formin-driven actin polymerization in vitro, but not …
biological studies. It inhibits formin-driven actin polymerization in vitro, but not …
Actin polymerization downstream of integrins: signaling pathways and mechanotransduction
A cell constantly adapts to its environment. Cell decisions to survive, to proliferate or to
migrate are dictated not only by soluble growth factors, but also through the direct interaction …
migrate are dictated not only by soluble growth factors, but also through the direct interaction …
Integrating actin dynamics, mechanotransduction and integrin activation: the multiple functions of actin binding proteins in focal adhesions
C Ciobanasu, B Faivre, C Le Clainche - European journal of cell biology, 2013 - Elsevier
Focal adhesions are clusters of integrin transmembrane receptors that mechanically couple
the extracellular matrix to the actin cytoskeleton during cell migration. Focal adhesions …
the extracellular matrix to the actin cytoskeleton during cell migration. Focal adhesions …
[HTML][HTML] The compass to follow: Focal adhesion turnover
M Mavrakis, MA Juanes - Current Opinion in Cell Biology, 2023 - Elsevier
How cells move is a fundamental biological question. The directionality of adherent
migrating cells depends on the assembly and disassembly (turnover) of focal adhesions …
migrating cells depends on the assembly and disassembly (turnover) of focal adhesions …